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SAN FRANCISCO — One person was killed in a drive-by shooting Thursday afternoon on a busy highway leading out of San Francisco. 

The shooting happened at about 2 p.m. The victim, driving a white Chevy Caprice on Highway 280, was shot and killed when a gray Nissan Maxima with chrome wheels and tinted windows pulled up beside his car and the occupants began shooting. 

After the driver was hit, his car spun out, but did not hit anyone else. His female passenger was not hit, and no one else was injured, said Shawn Chase, a California Highway Patrol spokesman. The victim’s name has not been released. 

There were at least two men in the Maxima, Chase said. All of the people in both cars were in their late teens or early 20s. Authorities are investigating the possibility that the victim knew the suspects. 

Police recovered the abandoned Nissan later in the evening and formed a perimeter around a house where they believe the suspect may live, said San Francisco Police Sgt. Anthony Manfreda. The suspect’s name has not been released. 

After the shooting, three lanes of southbound Highway 280 in the area just south of the San Jose Avenue onramp remained closed for at least three hours, backing up rush-hour traffic. 

Police do not know if the incident was gang-related. Authorities said both men could be armed.